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ea0029oc7.4 | Adrenal Clinical | ICEECE2012

Differential diagnosis of primary aldosteronism by peripheral plasma levels of 18-oxo-cortisol: a noninvasive method with a high specificity

Satoh F. , Morimoto R. , Kudo M. , Iwakura Y. , Ono Y. , Takase K. , Nakamura Y. , Sasano H. , Ito S.

18-Oxocortisol (18-oxoF) is a derivative of cortisol (F) that is produced by aldosterone synthase (CYP11B2), and its clinical usefulness has not been clarified. We prospectively measured 18-oxoF, using highly sensitive liquid chromatography-tandem mass spectrometry (LC/MS/MS), in peripheral plasma of patients with primary aldosteronism (PA) who underwent adrenal venous sampling (AVS) to differentiate aldosterone producing adenoma (APA) from bilateral hyperplasia. The study was...

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ea0029p294 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

In primary aldosteronism, plasma aldosterone concentration is an independent risk factor for albuminuria, and the higher baseline urinary albumin excretion predicts the less glomerular filtration rate after treatment

Iwakura Y. , Morimoto R. , Kudo M. , Ono Y. , Ito S. , Satoh F.

Background: The higher prevalence of urinary albumin was reported in patients with primary aldosteronism (PA) than those with essential hypertension (EH). It remains to be unclear, although glomerular hyperfiltration (HF) was hypothesized as one of the mechanisms of urinary albumin.Objectives: To clarify the risk factor of urinary albumin and the relationship with HF in PA.Methods: 123 patients with PA were treated acco...

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ea0029p35 | Adrenal cortex | ICEECE2012

Differential DNA methylation of the CYP11B1 and CYP11B2 genes in association with human adrenal zonation

Demura M. , Wang F. , Yoneda T. , Kometani M. , Sawamura T. , Cheng Y. , Ono K. , Nakamura Y. , Sasano H. , Saijoh K. , Takeda Y.

Background: The human adrenal cortex is composed of 3 distinct zones: the zona glomerulosa (ZG), the zona fasciculata (ZF), and the zona reticularis (ZR). Steroidogenic enzymes are expressed in a zone-specific manner. The promoters of CYP11B1 and CYP11B2 possess a number of target sites for DNA methylation that is closely associated with gene silencing.Methods and Materials: Adrenals from 5 autopsy subjects were assessed for immunohistrochemically define...

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Endocrine Abstracts

Differential diagnosis of primary aldosteronism by peripheral plasma levels of 18-oxo-cortisol: a noninvasive method with a high specificity

In primary aldosteronism, plasma aldosterone concentration is an independent risk factor for albuminuria, and the higher baseline urinary albumin excretion predicts the less glomerular filtration rate after treatment

Differential DNA methylation of the CYP11B1 and CYP11B2 genes in association with human adrenal zonation

BiosciAbstracts